A Case of Pathological Complete Response after “Conversion Surgery” for Initially Unresectable Locally Advanced Intrahepatic Cholangiocarcinoma

Yasunori Shirakawa, et al.

INTRODUCTION: Intrahepatic cholangiocarcinoma (iCCA) is the second most common liver cancer and has a poor prognosis. Given the recent advancements in drug therapy, the topic of so-called “conversion surgery” in biliary tract cancer, including iCCA, is evolving; however, only a few cases have been reported.

A Case of Pleomorphic-Type Anaplastic Carcinoma of the Pancreas with Rapidly Progressive and Fatal Cardiac Metastasis

Keiichi Shigematsu, et al.

INTRODUCTION: Cardiac metastasis from pancreatic ductal adenocarcinoma (PDAC) is extremely rare. Pleomorphic-type anaplastic carcinoma of the pancreas (PACP) is an uncommon, highly aggressive PDAC variant with lymphatic and hematogenous spread and poor prognosis. We report, to our knowledge, the first PACP case with antemortem diagnosis of cardiac metastasis and a rapidly fatal course.

Infective Endocarditis due to Esophageal Squamous Cell Carcinoma Invasion of the Left Atrium: A Case Report

Takeru Nakamura, et al.

INTRODUCTION: Esophageal cancer is often diagnosed at an advanced stage and with distant metastases. While cardiac metastases from solid tumors have been reported in 0.2%–6.5% of postmortem cases, solitary cardiac metastases remain exceedingly rare. Infective endocarditis, a life-threatening condition typically associated with valvular involvement and bacteremia, has not been widely associated with cardiac metastases. Here, we present an extremely rare case of esophageal squamous cell carcinoma directly invading the left atrium during chemotherapy, which was further complicated by infective endocarditis.

An 8-Year Survivor after Three-Time Hepatectomies for Metachronous Pancreatic Adenocarcinoma Liver Metastases

Toshiro Masuda, et al.

INTRODUCTION: Recurrence of pancreatic ductal adenocarcinoma (PDAC) after primary resection remains a challenging condition, and operative indications for metachronous liver metastases are limited.

Laparoscopic Resection of a Diaphragmatic Phrenic Neurilemmoma Compressing the Suprahepatic Inferior Vena Cava Following Thoracoscopic Exploration: A Case Report

Masashi Tsunematsu, et al.

INTRODUCTION: Surgical resection of tumors compressing the suprahepatic inferior vena cava (IVC) is challenging, as such lesions may require vascular resection, reconstruction, or extracorporeal circulation. We present a case of a diaphragmatic phrenic neurilemmoma severely compressing the suprahepatic IVC and right hepatic vein, which was successfully resected laparoscopically with both thoracoscopic and laparoscopic assessment.

Surgical Resection with Posterior Rectus Sheath Preservation and Mesh Reconstruction without Pursuing Wide Negative Margins for an Abdominal Wall Desmoid in Familial Adenomatous Polyposis: A Case Report

Makoto Hasegawa, et al.

INTRODUCTION: Desmoid tumors are locally aggressive, non-metastatic neoplasms that develop in up to 20% of patients with familial adenomatous polyposis (FAP). While active surveillance is the initial approach, surgery may be indicated for symptomatic or progressive disease; however, the optimal surgical strategy remains debated.

Protein-Losing Enteropathy Caused by Ascending Colon Cancer without Polyposis: A Rare Case Diagnosed by Scintigraphy

Hisanori Miki, et al.

INTRODUCTION: We report a rare case of protein-losing enteropathy (PLE) caused by ascending colon cancer without associated polyposis, a clinical entity that has been scarcely documented in the literature.

Atypical Intestinal Metastases from Invasive Lobular Carcinoma of the Breast: Two Surgical Cases Mimicking Primary Gastrointestinal Tumors

Yusuke Kitagawa, et al.

INTRODUCTION: Gastrointestinal metastasis arising from invasive lobular carcinoma (ILC) of the breast is a rare but clinically significant manifestation. Unlike invasive ductal carcinoma, ILC has a higher propensity to metastasize into the gastrointestinal (GI) tract, often presenting with non-specific symptoms and mimicking primary GI tumors. Its accurate diagnosis requires a high index of suspicion and immunohistochemical (IHC) confirmation. Herein, we report 2 cases of intestinal metastases from ILC presenting with bowel stenosis.

Metachronous Isolated Inguinal Lymph Node Metastasis at a Previous Hernia Repair Site following Potentially Curative Surgery for Transverse Colon Cancer: A Case Report

Hiroyuki Fujimoto, et al.

INTRODUCTION: Inguinal lymph node metastasis from colon cancer is extremely rare. Therapeutic strategies have not been established regarding preventive measures for hernia recurrence following mesh removal when the mesh used in inguinal hernia repair is infiltrated by a tumor. Similarly, no treatment strategies have been developed regarding the necessity of prophylactic orchiectomy when a tumor infiltrates the spermatic cord and requires resection.

A Case of Fulminant Amebiasis in a Female Commercial Sex Worker in Japan Requiring Subtotal Colectomy: A Literature Review and Case Report

Seigo Kubota, et al.

INTRODUCTION: Fulminant amebiasis is a rare, potentially lethal condition caused by Entamoeba histolytica. It causes intestinal perforation and generalized peritonitis, and treatment requires an emergency operation and the administration of anti-amoebic drugs. Although E. histolytica infections are more commonly reported in men who have sex with men, we report a successfully treated case of fulminant amebiasis in a female commercial sex worker (CSW). This report presents a review of previously reported cases.

Conversion Surgery after Complete Response to Immune Checkpoint Inhibitor-Based Sequential Chemotherapy for Initially Unresectable Perihilar Cholangiocarcinoma: A Case Report

Takahiro Tomino, et al.

INTRODUCTION: Perihilar cholangiocarcinoma (PHCC) is often diagnosed at an advanced stage, and surgical resection is frequently precluded due to local progression, distant metastases, or insufficient liver remnant function. Although systemic chemotherapy has recently improved outcomes in unresectable biliary tract cancer, reports of conversion surgery after achieving pathological complete response (pCR) remain extremely rare, thus the role of salvage surgery remains unclear.

Ischemic Colitis with Perforation Occurring 15 Months after Colorectal Cancer Surgery in a Patient with Severe Heart Failure: A Case Report

Ryosuke Machi, et al.

INTRODUCTION: Ischemic colitis is a common gastrointestinal disorder. However, severe cases requiring surgical intervention are rare. Severe ischemic colitis is particularly uncommon following surgery for colorectal cancer, with a reported incidence of only 0.7%. To our knowledge, there have been no previous reports of ischemic colitis leading to perforation in the late postoperative period following colorectal cancer surgery. Herein, we report a rare case of ischemic colitis that developed following surgery for transverse colon cancer and progressed to colonic perforation despite conservative treatment, ultimately necessitating emergency surgery.