Surgical Management of Destructive Thyroiditis Triggered by Neoadjuvant Immune Checkpoint Inhibitor Therapy in Locally Advanced Non-Small Cell Lung Cancer: A Case Report

Sachi Kawagishi, et al.

INTRODUCTION: The use of immune checkpoint inhibitors (ICIs) as neoadjuvant therapies for locally advanced and resectable non-small cell lung cancer is increasing. As a result, immune-related adverse events (irAEs) may be observed before surgery and may require preoperative intervention. We report the case of a patient with destructive thyroiditis induced by neoadjuvant ICI treatment, in which surgical resection was performed after steroid treatment.

Combined Endoscopic Submucosal Dissection and Transanal Minimally Invasive Surgery for Rectal Laterally Spreading Tumor after Prior Transanal Resection: A Case Report

Takashi Inoue et al.

INTRODUCTION: Endoscopic submucosal dissection (ESD) is an effective procedure for resecting noninvasive colorectal neoplasms. However, submucosal fibrosis affects the technical difficulty of ESD. We experienced a combined ESD and transanal minimally invasive surgery (TAMIS) for a rectal neoplasm with submucosal fibrosis.

Organ Donation after Open Abdominal Management with Negative-Pressure Dressing: A Case Report

Hiroshi Matsumoto, et al.

INTRODUCTION: The shortage of organ donors is a major challenge in transplantation. Expanding donor eligibility criteria can help increase the donor pool, but it is crucial to carefully assess the risks related to infections in donors with expanded criteria. Organ donation from trauma patients who have undergone open abdominal management (OAM) is uncommon because of concerns regarding organ damage and infection risk. However, with appropriate OAM and stringent infection control, safe organ donation may be possible.

Late Graft Failure Due to Arterio-Venous Fistula in the Free Jejunal Graft Mesentery Following Total Pharyngo-Laryngo-Esophagectomy for Cervical Esophageal Cancer: A Case Report

Koutarou Yamamoto, et al.

INTRODUCTION: Insufficient blood supply to free jejunal grafts after total pharyngo-laryngo-esophagectomy (TPLE) occurs primarily due to failure of the vascular anastomosis, often resulting in rapid graft necrosis. This report details a case of ischemic enteritis caused by an arteriovenous fistula (AVF) in the mesentery of the free jejunal graft, resulting in chronic stenosis and total removal of the jejunal graft.

Mycophenolate Mofetil for Steroid-Refractory Immune-Related Hepatitis and Sclerosing Cholangitis Following Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer: A Case Report

Hideto Iguchi et al.

INTRODUCTION: Neoadjuvant chemoimmunotherapy is increasingly regarded as the standard treatment for resectable non-small cell lung cancer. Although it improves survival outcomes, immune-related adverse events can delay or prevent curative surgery. Optimal strategies for managing these adverse events in the preoperative setting remain unclear. This case is notable for being, to the best of our knowledge, the first to report curative surgery following treatment of neoadjuvant chemoimmunotherapy-induced, steroid-refractory immune-related hepatitis using mycophenolate mofetil.

Worsening Ileal Stenosis Caused by Multiple Ectopic Gastric Mucosa Lesions in an Elderly Patient: A Novel Case with a Long Observation Period

Ryozan Naito, et al.

INTRODUCTION: Ectopic gastric mucosa (EGM) is a hyperplastic primitive gut epithelium found in tissues other than the stomach. EGM in the small intestine, distal to the ligament of Treitz (EGMdT), is uncommon. EGMdT without congenital anomalies has rarely been reported. Most reported cases are diagnosed in youth, with a single lesion and urgent symptoms requiring emergency surgery. Herein, we report a unique case of multiple EGMdTs without congenital anomalies that caused progressive ileal stenosis in an elderly patient with an observation period of 11 years.

Male Occult Primary Breast Cancer Diagnosed with Small Bowel Metastases: A Case Report

Suguru Ogata et al.

INTRODUCTION: Male occult breast cancers are extremely rare and often difficult to diagnose. With only few cases reported, no established treatment is available. And metastatic spread to the small intestine from a tumor originating outside the peritoneal cavity is rare. However, there is a higher tendency for metastasis to the peritoneal cavity, including the small bowel, in the case of lobular carcinoma of the breast.

Experience with Laparoscopic Surgery for Rectal Obstruction Caused by Intestinal Endometriosis with a Frozen Pelvis: A Case Report

Hisashi Ro, et al.

INTRODUCTION: While intestinal obstruction is common, intestinal endometriosis is relatively rare, making its etiology still poorly understood. We report a case of rectal obstruction caused by intestinal endometriosis with a frozen pelvis, treated with laparoscopy in collaboration with gynecologists.

A Case of Rendezvous Dilation under Laparotomy for Pancreaticojejunostomy Stricture after Pancreaticoduodenectomy

Masaharu Ishida, et al.

INTRODUCTION: Pancreatico-enterostomy stenosis is a late postoperative complication following pancreaticoduodenectomy. We report a case in which a surgical “rendezvous” procedure was performed to address the stenosis.

Promising Treatment Strategy for Primary Malignant Melanoma of the Esophagus by Radical Esophagectomy and Nivolumab as Adjuvant Therapy: A Case Report

Yusuke Yamamoto, et al.

INTRODUCTION: Primary malignant melanoma of the esophagus (PMME) is a rare malignant tumor of the esophagus with very poor prognosis due to high rates of recurrence and metastasis even after radical resection. Recently, however, immune checkpoint inhibitors such as anti-programmed cell death-1 antibodies have been suggested to improve the prognosis of malignant melanoma. This report describes the use of postoperative nivolumab as adjuvant therapy after surgical resection of PMME, with recurrence-free follow-up for more than 1 year.

Complete Resection of Cardiac Metastasis Myxoid Liposarcoma

Kazuhiro Yamazaki, et al.

INTRODUCTION: Myxoid liposarcoma rarely metastasizes to the heart. Therefore, diagnosing cardiac metastases of myxoid liposarcoma is challenging, and treatment is often ineffective. Here, we report a case of cardiac metastasis from a myxoid liposarcoma detected using whole-body MRI, which was successfully treated with a multidisciplinary approach, including surgery, resulting in favorable outcomes.

Partial Thymectomy during Tracheostomy for Superior Herniation of Normal Mediastinal Thymus in a Patient with Larsen Syndrome: A Case Report

Atsushi Yoshiyama, et al.

INTRODUCTION: Superior herniation of the mediastinal thymus is a rare cause of neck mass, characterized by intermittent migration of normal thymic tissue into the suprasternal region due to increased intrathoracic pressure. Generally, thymus resection is discouraged to avoid inducing athymia and subsequent immunodeficiency in the child. To date, no prior cases of tracheostomy combined with partial thymectomy have been reported. We present a case in which partial resection of the thymus was necessary to facilitate a tracheostomy.